Recent peer-reviewed highlights

  1. Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis.
    Hazelwood, E., Sanderson, E., Tan, V.Y., Ruth, K.S., Frayling, T.M., Dimou, N., Gunter, M.J., Dossus, L., Newton, C., Ryan, N., Pournaras, D.J., O’Mara, T.A., Smith, G.D., Martin, R.M. & Yarmolinsky, J., 19 Apr 2022, In: BMC Medicine. 20(1):125. PMID: 35436960

  2. Applying Mendelian randomization to appraise causality in relationships between nutrition and cancer.
    Wade, K., Yarmolinsky, J., Giovannucci, E., Lewis, S. J., Millwood, I. Y., Munafo, M. R., Meddens, F., Burrows, K., Bell, J. A., Davies, N. M., Mariosa, D., Kanerva, N., Vincent, E. E., Smith-Byrne, K., Guida, F., Gunter, M. J., Sanderson, E., Dudbridge, F., Burgess, S., Cornelis, M. C. & 19 others, , 10 Feb 2022, (Accepted/In press) In: Cancer Causes and Control. PMID: 35274198

  3. Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis.
    Goudswaard, L. J., Corbin, L. J., Burley, K. L., Mumford, A. D., Akbari, P., Soranzo, N., Butterworth, A., Watkins, N. A., Pournaras, D. J., Harris, J. M., Timpson, N. J. & Hers, I., 24 Jan 2022, In: Platelets. p. 1-10 10 p. PMID: 35068290

  4. A framework for research into continental ancestry groups of the UK Biobank.
    Constantinescu, A-E., Mitchell, R. E., Zheng, J., Bull, C. J., Timpson, N. J., Amulic, B., Vincent, E. E. & Hughes, D. A., 29 Jan 2022, In: Human Genomics. 16, 1. PMID: 35093177

  5. Epigenetic Regulation of F2RL3 Associates with Myocardial Infarction and Platelet Function.
    Corbin, L. J., White, S. J., Taylor, A. E., Williams, C. M., Taylor, K., Van Den Bosch, M. T. J., Teasdale, J. E., Jones, M. L., Bond, M., Harper, M. T., Falk, L., Groom, A., Hazell, G. G. J., Paternoster, L., Munafo, M. R., Nordestgaard, B. G., Tybjaerg-Hansen, A., Bojesen, S. E., Relton, C. L., Min, J. L. & 4 others, , 11 Jan 2022. In: Circulation Research. PMID: 35012325

  6. Abuse in childhood and cardiometabolic health in early adulthood: evidence from the Avon Longitudinal Study of Parents and Children.
    Goncalves Soares, A. L. , Zimmerman, A., Zammit, S., Karl, A., Halligan, S. L. & Fraser, A., 7 Dec 2021, In: Journal of the American Heart Association. PMID: 34873916

  7. GWAS of stool frequency provides insights into gastrointestinal motility and irritable bowel syndrome.
    Bonfiglio, F., Liu, X., Smillie, C., Pandit, A., Timpson, N. J., Kurilshikov, A., Bacigalupe, R., Zheng, T., Nim, H., Garcia-Etzebarria, K., Bujanda, L., Andreasson, A., Agreus, L., Walter, S., Abecasis, G. R., Eijsbouts, C., Jostins, L., Parkes, M., Hughes, D. A., Raes, J. & 7 others, 08 Dec 2021, In: Cell Genomics.

  8. MC3R links nutritional state to childhood growth and the timing of puberty.
    Lam B.Y.H., Williamson A., Finer S., Day F.R., Tadross J.A., Gonçalves Soares A., Wade K., Sweeney P., Bedenbaugh M.N., Porter D.T., Melvin A., Ellacott K.L.J., Lippert R.N., Buller S., Rosmaninho-Salgado J., Dowsett G.K.C., Ridley K.E., Xu Z., Cimino I., Rimmington D., Rainbow K., Duckett K., Holmqvist S., Khan A., Dai X., Bochukova E.G., Genes & Health Research Team; Trembath R.C., Martin H.C., Coll A.P., Rowitch D.H., Wareham N.J., van Heel D.A., Timpson N.J., Simerly R.B., Ong K.K., Cone R.D., Langenberg .C, Perry J.R.B., Yeo G.S., O'Rahilly S., In: Nature Nov 3 2021, ahead of print. PMID: 34732894

  9. The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium.
    Guida F., Tan V.Y., Corbin L.J., Smith-Byrne K., Alcala K., Langenberg C., Stewart I.D., Butterworth A.S., Surendran P., Achaintre D., Adamski J., Amiano Exezarreta P., Bergmann M.M., Bull C.J., Dahm C.C., Gicquiau A., Giles G.G., Gunter M.J., Haller T., Langhammer A., Larose T.L., Ljungberg B., Metspalu A., Milne R.L., Muller D.C., Nøst T.H., Pettersen Sørgjerd E., Prehn C., Riboli E., Rinaldi S., Rothwell J.A., Scalbert A., Schmidt J.A., Severi G., Sieri S., Vermeulen R., Vincent E.E., Waldenberger M., Timpson N.J., Johansson M., Epub ahead of print Sep 20 2021, In: PLoS Med. PMID: 34543281

  10. Investigation of the interplay between circulating lipids and IGF-I and relevance to breast cancer risk: an observational and Mendelian randomization study.
    Tan V., Bull C.J.,, 1 Jan 2021, In: Cancer Epidemiol Biomarkers Prev.: here

  11. Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates.
    Goudswaard, L. J., Bell, J. A., Hughes, D. A., Corbin, L. J., Walter, K., Davey Smith, G., Soranzo, N., Danesh, J., Di Angelantonio, E., Ouwehand, W. H., Watkins, N. A., Roberts, D., Butterworth, A. S., Hers, I. & Timpson, N. J., 5 Jul 2021, In: International Journal of Obesity. PMID: 34226637

  12. The Trans-Ancestral Genomic Architecture of Glycemic Traits.
    Chen, J., Spracklen, C. N., Marenne, G., Varshney, a., Corbin, L. J., [..] The Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC). 31 May 2021. PMID: 34059833

  13. The role of inflammatory cytokines as intermediates in the pathway from increased adiposity to disease.
    Kalaoja, M., Corbin, L. J., Tan, Y., Ahola-Olli, A. V., Havulinna, A. S., Santalahti, K., Pitkänen, N., Lehtimäki, T., Lyytikäinen, L. P., Raitoharju, E., Seppala, I., Kahonen, M., Ripatti, S., Palotie, A., Perola, M., Viikari, J., Jalkanen, S., Maksimow, M., Salomaa, V., Salmi, M. & 3 others, , 1 Feb 2021, In: Obesity. 29, 2, p. 428-437 10 p. PMID: 33491305

  14. How does childhood maltreatment influence cardiovascular disease? A sequential causal mediation analysis.
    Goncalves Soares, A. L., Howe, L. D., Heron, J. E., Hammerton, G. L., Rich-Edwards, J. W., Magnus, M. C., Halligan, S. L. & Fraser, A., 25 Mar 2021, In: International Journal of Epidemiology. PMID: 34041541

  15. Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort.
    Wade, K. H., Lam, B. Y. H., Melvin, A., Pan, W., Corbin, L. J., Hughes, D. A., Rainbow, K., Chen, J. H., Duckett, K., Liu, X., Mokrosińsk, J., Mörseburg, A., Neaves, S., Williamson, A., Zhang, C., Farooqi, I. S., Yeo, G. S. H., Timpson, N. J. & O'Rahilly, S., 27 May 2021, In: Nature Medicine. (2021), 26 p. PMID: 34045736

  16. Do inflammation and adiposity mediate the association of diet quality with depression and anxiety in young adults?
    Gomes, A. P., Gonçalves, H., Vaz, J. D. S., Kieling, C., Rohde, L. A., Oliveira, I. O. & Goncalves Soares, A. L., 1 May 2021, In: Clinical Nutrition. 40, 5, p. 2800-2808 9 p. PMID: 33933746

  17. Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study.
    Bull, C. J., Bell, J. A., Sanderson, E., Davey Smith, G., Timpson, N. J., Vincent, E. E. & Gunter, M. J., 17 Dec 2020, In: BMC Medicine. 18, 16 p., 396 (2020). PMID: 33327948

  18. Improving causality in microbiome research: can human genetic epidemiology help?
    Wade, K. H. & Hall, L. J., 24 Apr 2020, In: Wellcome Open Research. 4, 16 p., 199. PMID: 32462081

  19. Common variation at 16p11.2 is associated with glycosuria in pregnancy: Findings from a genome-wide association study in European women.
    Lee, M., McMahon, G., Karhunen, V., Wade, K. H., Corbin, L. J., Hughes, D. A., Davey Smith, G., Lawlor, D. A., Jarvelin, M-R. & Timpson, N. J., 15 Jun 2020, In: Human Molecular Genetics. 29, 12, p. 9 2098 p. PMID: 32227112

  20. Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early life.
    Bell, J. A., Bull, C. J., Gunter, M. J., Carslake, D., Mahajan, A., Davey Smith, G., Timpson, N. J. & Vincent, E. E., 28 Apr 2020, In: Diabetes Care. dc192348. PMID: 32345654

  21. Genome-wide associations of human gut microbiome variation and implications for causal inference analyses.
    Hughes, D. A., Bacigalupe, R., Wang, J., Rühlemann, M., Tito, R., Falony, G., Joossens, M., Vieira-Silva, S., Henckaerts, L., Rymenans, L., Verspecht, C., Ring, S. M., Franke, A., Wade, K. H., Timpson, N. J. & Raes, J., 22 Jun 2020, In: Nature Microbiology. 5, p. 1079–1087 9 p. PMID: 32572223

  22. Metabolic characterisation of disturbances in the APOC3/triglyceride-rich lipoprotein pathway through sample-based recall by genotype.
    Corbin, L., Hughes, D. A., Chetwynd, A. J., Taylor, A. E., Southam, A. D., Ratcliffe, A., Jankevics, A., Weber, R. J. M., Groom, A., Dunn, W. B. & Timpson, N. J., 3 Jun 2020, In: Metabolomics. (2020) 16, 69, 12 p. PMID: 32494907

  23. Piloting the objective measurement of eating behaviour at a population-scale: a nested study within the Avon Longitudinal Study of Parents and Children.
    Wade, K. H., Clifford, L., Simpkin, A. J., Beynon, R. A., Birch, L., Northstone, K., Matthews, S. M., Davey Smith, G., Shield, J. P. H. & Timpson, N. J., 7 Oct 2020, (Submitted) In: Wellcome Open Research

  24. Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis.
    Haworth, S, Mitchell, R, Corbin, L, Wade, K, Dudding, T, Budu-Aggrey, A, Carslake, D, Hemani, G, Paternoster, L, Smith, GD, Davies, N, Lawson, D & Timpson, N, 2019. Nature Communications, vol 10. PMID: 30659178

  25. Assessment of reproducibility and biological variability of fasting and postprandial plasma metabolite concentrations using 1H NMR spectroscopy.
    Li-Gao, R., Hughes, D. A., le Cessie, S., de Mutsert, R., den Heijer, M., Rosendaal, F. R., Willems van Dijk, K., Timpson, N. J. & Mook-Kanamori, D. O., 20 Jun 2019. PLoS ONE. 14, 6, e0218549. PMID: 31220183

  26. Is Population Structure in the genetic biobank era irrelevant, a challenge, or an opportunity?
    Lawson, D., Davies, N., Haworth, S., Ashraf, B., Howe, L., Crawford, A., Hemani, G., Davey Smith, G. & Timpson, N., 27 Apr 2019. PMID: 31030318

Conference Talks & Posters

  1. Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis.
    Emma Hazelwood, Richard Martin, James Yarmolinsky. Presented as a talk and poster at: National Cancer Research Institute Cancer Conference. In addition, Emma was awarded the "NCRI Award" for a high quality abstract. Read the abstract here.

  2. The relationships between body mass index and metabolite response to a standardized meal challenge.
    David A. Hughes, Ruifang Li-Gao, Caroline J. Bull, Laura J. Corbin, Renée de Mutsert, Frits R. Rosendaal, Dennis O. Mook-Kanamori, Ko Willems van Dijk, Nicholas J. Timpson. Presented at: Metabolomics 2021 & IGES 2021. Download poster here.

  3. Metabolic features of colorectal cancer liability: life course study integrating genetic risk with repeated metabolomics.
    CJ Bull, JA Bell, N Murphy, JR Huyghe, NJ Timpson, MJ Gunter, EE Vincent. Presented at: The MR Conference 2021. Download poster here.

  4. Investigating a causal role for neutrophil count on P. falciparum severe malaria: a Mendelian Randomization study.
    Andrei Constantinescu, David Hughes, Ruth Mitchell, Borko Amulic, Jie Zheng, Caroline Bull, Siddhartha Kar, Nicholas Timpson, Emma Vincent. Presented at: The MR Conference 2021. Download poster here.

Contributions to COVID-19 Research

  1. Mental health before and during COVID-19 in two longitudinal UK population cohorts.
    Kwong, A. S. F., Pearson, R. M., Adams, M. J., Northstone, K., Tilling, K., Smith, D., Fawns-Ritchie, C., Bould, H., Warne, N., Zammit, S., Gunnell, D., Moran, P., Micali, N., Reichenberg, A., Hickman, M., Rai, D., Haworth, S., Campbell, A., Altschul, D., Flaig, R. & 4 others, , 24 Nov 2020, In: British Journal of Psychiatry. 10 p. PMID: 33228822

  2. The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture May-July 2020.
    Northstone, K., Smith, D., Bowring, C. E., Wells, N. S., Crawford, M., Haworth, S. J. & Timpson, N. J., 22 Sep 2020, In: Wellcome Open Research. 5, 210, 16 p. PMID: 32995559

  3. The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture April-May 2020.
    Northstone, K., Haworth, S., Smith, D., Bowring, C., Wells, N. & Timpson, N. J., 10 Jun 2020, In: Wellcome Open Research. 10 p. PMID: 33628949