Publications

Recent preprint and peer-reviewed highlights

  1. Impact of weight loss on cancer-related proteins in serum: results from a cluster randomised controlled trial of individuals with type 2 diabetes.
    Caroline J. Bull, Emma Hazelwood, Danny N. Legge, Laura J. Corbin, Tom G. Richardson, Matthew Lee, James Yarmolinsky, Karl Smith-Byrne, David A. Hughes, …, Nicholas J. Timpson, Emma E. Vincent, eBioMedicine 100, 104977, February, 2024. here

  2. Prenatal urban environment and blood pressure trajectories from childhood to early adulthood
    Ana Gonçalves Soares, …, Ahmed Elhakeem, Nicholas J Timpson. JACC: Advances 3 (2), 100808. February, 2024. here

  3. Challenges in undertaking nonlinear Mendelian randomization.
    Kaitlin H Wade, Fergus W Hamilton,David Carslake, Naveed Sattar, George Davey Smith, Nicholas J Timpson. Obesity 31 (12), 2887-2890. December 2023 here

  4. Using trials of caloric restriction and bariatric surgery to explore the effects of body mass index on the circulating proteome.
    Goudswaard LJ, Smith ML, Hughes DA, Taylor R, Lean M, Sattar N, Welsh P, McConnachie A, Blazeby JM, Rogers CA, Suhre K, Zaghlool S, Hers I, & Timpson NJ, Corbin LJ. 29 Nov 2023, (Published) here

  5. The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT).
    Laura J. Corbin, David A. Hughes, Caroline J. Bull, Emma E. Vincent, Madeleine L. Smith, Alex McConnachie, Claudia-Martina Messow, Paul Welsh, Roy Taylor, Michael E. J. Lean, Naveed Sattar & Nicholas J. Timpson. 15 Oct 2023, (E-pub ahead of print) here

  6. Circulating white blood cell traits and colorectal cancer risk: A Mendelian randomization study.
    Constantinescu, A-E., Bull, C. J.,, Jones, N., Mitchell, R., Burrows, K., Dimou, N., Bézieau, S., Brenner, H., Buchanan, D. D., D'Amato, M., Jenkins, M. A., Moreno, V., Pai, R. K., Um, C. Y., White, E., Murphy, N., Gunter, M., Timpson, N. J., Huyghe, J. R. & Vincent, E. E., 14 Aug 2023, (E-pub ahead of print) In: International Journal of Cancer. PMID: 37578112

  7. Prenatal urban environment and blood pressure trajectories from childhood to early adulthood.
    Soares AG, Santos S, Seyve E, Nedelec R, Puhakka S, Eloranta A-M, Mikkonen S, Yuan WL, Lawlor DA, Heron J, ..., Elhakeem A, Timpson NJ. medRxiv 2023:2023.2003.2031.23288002; doi: 10.1101/2023.03.31.23288002. preprint

  8. Application of Mendelian randomization to explore the causal role of the human gut microbiome in colorectal cancer.
    Hatcher C, Richenberg G, Waterson S, Nguyen LH, Joshi AD, Carreras-Torres C, Moreno V, Chan AT, Gunter M, Lin Y, Qu C, Song M, Casey G, Figueiredo JC, Gruber SB, Hampe J, Hampel H, Jenkins MA, Keku TO, Peters U, Tangen CM, Wu AH, Hughes DA, Rühlemann MC, Raes J, Timpson NJ & Wade KH. Sci Rep. 2023 Apr 12;13(1):5968. doi: 10.1038/s41598-023-31840-0. PMID: 37045850

  9. Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization study.
    Smith ML, Bull CJ, Holmes MV, Davey Smith G, Sanderson E, Anderson EL, Bell JA. EBioMedicine. 2023 Mar 2;90:104503. PMID: 36870196

  10. Mediators of the association between childhood body mass index and educational attainment: Analysis of a UK prospective cohort study.
    Bowman K, Cadman T, Goncalves Soares A, Robinson O, Hughes A, Heron J, Segal AB, Huerta MC, Howe LD. Pediatr Obes. 2023 Feb 23;e13014. PMID: 36823984

  11. Variation in ERAP2 has opposing effects on severe respiratory infection and autoimmune disease.
    Hamilton F, Mentzer AJ, Parks T, Baillie JK, Davey Smith G, Ghazal P, Timpson NJ. Am J Hum Genet. 2023 Feb 21;S0002-9297(23)00052-6, ahead of print. PMID: 36889308

  12. Altered IL-6 signalling and risk of tuberculosis disease: a meta-analysis and Mendelian randomisation study.
    Hamilton F, Schurz H, Yates TA, Gilchrist JJ, Möller M, Naranbhai V, Ghazal P, Timpson NJ; International Host TB Genetics Consortium; Parks T, Pollara G. medRxiv. 2023 Feb 8;2023.02.07.23285472. PMID: 36798349

  13. Loci for insulin processing and secretion provide insight into type 2 diabetes risk.
    Broadaway KA, Yin X, Williamson A, ..     Corbin LJ, Hughes DA, Timpson NJ, .. Langenberg C, Wheeler E, Mohlke KL. Am J Hum Genet. 2023 Feb 2;110(2):284-299.; PMID: 36693378

  14. Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study.
    Papadimitriou N, Bull CJ, Jenab M, Hughes DJ, Bell JA, Sanderson E, Timpson NJ, .. Vincent EE, Mariosa D, Gunter MJ, Richardson TG, Murphy N. Jan 2023, In: BMC Medicine. 4;21(1):5.; PMID: 36600297

  15. Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19.
    Goudswaard, LJ, Williams CM, Khalil J, Burley KL, Hamilton F, Arnold D, Milne A, Lewis PA, Heesom KJ, Mundell SJ, Davidson AD, Poole AW, Hers I. J Thromb Haemost. 2023 Jan 27:S1538-7836(23)00059-4.; PMID: 36716966

  16. Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study.
    Hamilton, F.W., Thomas, M., Arnold, D., Palmer, T., Moran, E., Mentzer, A. J., Maskell, N., Baillie, K., Summers, C., Hingorani, A., MacGowan, A., Khandaker, G. M., Mitchell, R., Davey Smith, G., Ghazal, P. & Timpson, N. J.. PLoS Med. 2023 Jan 30;20(1):e1004174.; PMID: 36716318

  17. A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits.
    Battram T, Gaunt TR, Relton CL, Timpson NJ,, Hemani G. Nat Commun 2022 Dec 19;13(1):7816.; PMID: 36535946

  18. Inflammation proteomics datasets in the ALSPAC cohort.
    Goulding, N. J., Goudswaard, L., Hughes, D. A., Corbin, L. J., Groom, A., Ring, S. M., Timpson, N.J., Fraser, A., Northstone, K. & Suderman, M. J., 9 Nov 2022, (Accepted/In press) In: Wellcome Open Research. 16 p.; doi: here

  19. HMOX1 STR polymorphism and malaria: an analysis of a large clinical dataset.
    Hamilton F,, Mitchell R, Cunnington A, Ghazal P, Timpson NJ. Malar J. 2022 Nov 17;21(1):342.; PMID: 36397106

  20. The UK Biobank: A Shining Example of Genome-Wide Association Study Science with the Power to Detect the Murky Complications of Real-World Epidemiology
    Tan VY, Timpson NJ. Annu Rev Genomics Hum Genet. 2022 Aug 31;23:569-589.; PMID: 35508184

  21. A multivariant recall-by-genotype study of the metabolomic signature of BMI
    Fang S, Wade KH, Hughes DA, Fitzgibbon S, Yip V, Timpson NJ, Corbin LJ. Obesity (Silver Spring). 2022 Jun;30(6):1298-1310.; PMID: 35598895

  22. HMOX1 genetic polymorphisms and outcomes in infectious disease: A systematic review
    Hamilton FW, Mitchell RE, Ghazal P & Timpson NJ. PLoS One. 2022 May 12;17(5):e0267399.; PMID: 35551540

  23. "Alexa, I just ate a donut”: A pilot study collecting food and drink intake data with voice input.
    Millard, L. AC., Johnson, L., Neaves, S.R., Flach, P.A, Tilling, K., Lawlor, D.A., medRxiv 2022.06.28.22276999; doi: here

  24. Comparison of intergenerational instrumental variable analyses of body mass index and mortality in UK Biobank.
    Barry, CJ, Carslake, D., Wade, K.H., Sanderson, E., Davey Smith, G., Int J Epidemiol. 2022 Aug 10:dyac159. doi: 10.1093/ije/dyac159. Epub ahead of print. PMID: 35947758

  25. Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis.
    Hazelwood, E., Sanderson, E.,     Tan, V.Y., Ruth, K.S., Frayling, T.M., Dimou, N., Gunter, M.J., Dossus, L., Newton, C., Ryan, N., Pournaras, D.J., O’Mara, T.A., Smith, G.D., Martin, R.M. & Yarmolinsky, J., 19 Apr 2022, In: BMC Medicine. 20(1):125. PMID: 35436960

  26. Applying Mendelian randomization to appraise causality in relationships between nutrition and cancer.
    Wade, K., Yarmolinsky, J., Giovannucci, E., Lewis, S. J., Millwood, I. Y., Munafo, M. R., Meddens, F., Burrows, K., Bell, J. A., Davies, N. M., Mariosa, D., Kanerva, N., Vincent, E. E., Smith-Byrne, K., Guida, F., Gunter, M. J., Sanderson, E., Dudbridge, F., Burgess, S., Cornelis, M. C. & 19 others, , 10 Feb 2022, (Accepted/In press) In: Cancer Causes and Control. PMID: 35274198

  27. Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis.
    Goudswaard, L. J., Corbin, L. J., Burley, K. L., Mumford, A. D., Akbari, P., Soranzo, N., Butterworth, A., Watkins, N. A., Pournaras, D. J., Harris, J. M., Timpson, N. J. & Hers, I., 24 Jan 2022, In: Platelets. p. 1-10 10 p. PMID: 35068290

  28. A framework for research into continental ancestry groups of the UK Biobank.
    Constantinescu, A-E., Mitchell, R. E., Zheng, J., Bull, C. J., Timpson, N. J., Amulic, B., Vincent, E. E. & Hughes, D. A., 29 Jan 2022, In: Human Genomics. 16, 1. PMID: 35093177

  29. Epigenetic Regulation of F2RL3 Associates with Myocardial Infarction and Platelet Function.
    Corbin, L. J., White, S. J., Taylor, A. E., Williams, C. M., Taylor, K., Van Den Bosch, M. T. J., Teasdale, J. E., Jones, M. L., Bond, M., Harper, M. T., Falk, L., Groom, A., Hazell, G. G. J., Paternoster, L., Munafo, M. R., Nordestgaard, B. G., Tybjaerg-Hansen, A., Bojesen, S. E., Relton, C. L., Min, J. L. & 4 others, , 11 Jan 2022. In: Circulation Research. PMID: 35012325

  30. Abuse in childhood and cardiometabolic health in early adulthood: evidence from the Avon Longitudinal Study of Parents and Children.
    Goncalves Soares, A. L. , Zimmerman, A., Zammit, S., Karl, A., Halligan, S. L. & Fraser, A., 7 Dec 2021, In: Journal of the American Heart Association. PMID: 34873916

  31. GWAS of stool frequency provides insights into gastrointestinal motility and irritable bowel syndrome.
    Bonfiglio, F., Liu, X., Smillie, C., Pandit, A., Timpson, N. J., Kurilshikov, A., Bacigalupe, R., Zheng, T., Nim, H., Garcia-Etzebarria, K., Bujanda, L., Andreasson, A., Agreus, L., Walter, S., Abecasis, G. R., Eijsbouts, C., Jostins, L., Parkes, M., Hughes, D. A., Raes, J. & 7 others, 08 Dec 2021, In: Cell Genomics.

  32. MC3R links nutritional state to childhood growth and the timing of puberty.
    Lam B.Y.H., Williamson A., Finer S., Day F.R., Tadross J.A., Gonçalves Soares A., Wade K., Sweeney P., Bedenbaugh M.N., Porter D.T., Melvin A., Ellacott K.L.J., Lippert R.N., Buller S., Rosmaninho-Salgado J., Dowsett G.K.C., Ridley K.E., Xu Z., Cimino I., Rimmington D., Rainbow K., Duckett K., Holmqvist S., Khan A., Dai X., Bochukova E.G., Genes & Health Research Team; Trembath R.C., Martin H.C., Coll A.P., Rowitch D.H., Wareham N.J., van Heel D.A., Timpson N.J., Simerly R.B., Ong K.K., Cone R.D., Langenberg .C, Perry J.R.B., Yeo G.S., O'Rahilly S., In: Nature Nov 3 2021, ahead of print. PMID: 34732894

  33. The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium.
    Guida F., Tan V.Y., Corbin L.J., Smith-Byrne K., Alcala K., Langenberg C., Stewart I.D., Butterworth A.S., Surendran P., Achaintre D., Adamski J., Amiano Exezarreta P., Bergmann M.M., Bull C.J., Dahm C.C., Gicquiau A., Giles G.G., Gunter M.J., Haller T., Langhammer A., Larose T.L., Ljungberg B., Metspalu A., Milne R.L., Muller D.C., Nøst T.H., Pettersen Sørgjerd E., Prehn C., Riboli E., Rinaldi S., Rothwell J.A., Scalbert A., Schmidt J.A., Severi G., Sieri S., Vermeulen R., Vincent E.E., Waldenberger M., Timpson N.J., Johansson M., Epub ahead of print Sep 20 2021, In: PLoS Med. PMID: 34543281

  34. Investigation of the interplay between circulating lipids and IGF-I and relevance to breast cancer risk: an observational and Mendelian randomization study.
    Tan V., Bull C.J., et.al., 1 Jan 2021, In: Cancer Epidemiol Biomarkers Prev.: here

  35. Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates.
    Goudswaard, L. J., Bell, J. A., Hughes, D. A., Corbin, L. J., Walter, K., Davey Smith, G., Soranzo, N., Danesh, J., Di Angelantonio, E., Ouwehand, W. H., Watkins, N. A., Roberts, D., Butterworth, A. S., Hers, I. & Timpson, N. J., 5 Jul 2021, In: International Journal of Obesity. PMID: 34226637

  36. The Trans-Ancestral Genomic Architecture of Glycemic Traits.
    Chen, J., Spracklen, C. N., Marenne, G., Varshney, a., Corbin, L. J., [..] The Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC). 31 May 2021. PMID: 34059833

  37. The role of inflammatory cytokines as intermediates in the pathway from increased adiposity to disease.
    Kalaoja, M., Corbin, L. J., Tan, Y., Ahola-Olli, A. V., Havulinna, A. S., Santalahti, K., Pitkänen, N., Lehtimäki, T., Lyytikäinen, L. P., Raitoharju, E., Seppala, I., Kahonen, M., Ripatti, S., Palotie, A., Perola, M., Viikari, J., Jalkanen, S., Maksimow, M., Salomaa, V., Salmi, M. & 3 others, , 1 Feb 2021, In: Obesity. 29, 2, p. 428-437 10 p. PMID: 33491305

  38. How does childhood maltreatment influence cardiovascular disease? A sequential causal mediation analysis.
    Goncalves Soares, A. L., Howe, L. D., Heron, J. E., Hammerton, G. L., Rich-Edwards, J. W., Magnus, M. C., Halligan, S. L. & Fraser, A., 25 Mar 2021, In: International Journal of Epidemiology. PMID: 34041541

  39. Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort.
    Wade, K. H., Lam, B. Y. H., Melvin, A., Pan, W., Corbin, L. J., Hughes, D. A., Rainbow, K., Chen, J. H., Duckett, K., Liu, X., Mokrosińsk, J., Mörseburg, A., Neaves, S., Williamson, A., Zhang, C., Farooqi, I. S., Yeo, G. S. H., Timpson, N. J. & O'Rahilly, S., 27 May 2021, In: Nature Medicine. (2021), 26 p. PMID: 34045736

  40. Do inflammation and adiposity mediate the association of diet quality with depression and anxiety in young adults?
    Gomes, A. P., Gonçalves, H., Vaz, J. D. S., Kieling, C., Rohde, L. A., Oliveira, I. O. & Goncalves Soares, A. L., 1 May 2021, In: Clinical Nutrition. 40, 5, p. 2800-2808 9 p. PMID: 33933746

  41. Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study.
    Bull, C. J., Bell, J. A., Sanderson, E., Davey Smith, G., Timpson, N. J., Vincent, E. E. & Gunter, M. J., 17 Dec 2020, In: BMC Medicine. 18, 16 p., 396 (2020). PMID: 33327948

  42. Improving causality in microbiome research: can human genetic epidemiology help?
    Wade, K. H. & Hall, L. J., 24 Apr 2020, In: Wellcome Open Research. 4, 16 p., 199. PMID: 32462081

  43. Common variation at 16p11.2 is associated with glycosuria in pregnancy: Findings from a genome-wide association study in European women.
    Lee, M., McMahon, G., Karhunen, V., Wade, K. H., Corbin, L. J., Hughes, D. A., Davey Smith, G., Lawlor, D. A., Jarvelin, M-R. & Timpson, N. J., 15 Jun 2020, In: Human Molecular Genetics. 29, 12, p. 9 2098 p. PMID: 32227112

  44. Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early life.
    Bell, J. A., Bull, C. J., Gunter, M. J., Carslake, D., Mahajan, A., Davey Smith, G., Timpson, N. J. & Vincent, E. E., 28 Apr 2020, In: Diabetes Care. dc192348. PMID: 32345654

  45. Genome-wide associations of human gut microbiome variation and implications for causal inference analyses.
    Hughes, D. A., Bacigalupe, R., Wang, J., Rühlemann, M., Tito, R., Falony, G., Joossens, M., Vieira-Silva, S., Henckaerts, L., Rymenans, L., Verspecht, C., Ring, S. M., Franke, A., Wade, K. H., Timpson, N. J. & Raes, J., 22 Jun 2020, In: Nature Microbiology. 5, p. 1079–1087 9 p. PMID: 32572223

  46. Metabolic characterisation of disturbances in the APOC3/triglyceride-rich lipoprotein pathway through sample-based recall by genotype.
    Corbin, L., Hughes, D. A., Chetwynd, A. J., Taylor, A. E., Southam, A. D., Ratcliffe, A., Jankevics, A., Weber, R. J. M., Groom, A., Dunn, W. B. & Timpson, N. J., 3 Jun 2020, In: Metabolomics. (2020) 16, 69, 12 p. PMID: 32494907

  47. Piloting the objective measurement of eating behaviour at a population-scale: a nested study within the Avon Longitudinal Study of Parents and Children.
    Wade, K. H., Clifford, L., Simpkin, A. J., Beynon, R. A., Birch, L., Northstone, K., Matthews, S. M., Davey Smith, G., Shield, J. P. H. & Timpson, N. J., 7 Oct 2020, (Submitted) In: Wellcome Open Research

  48. Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis.
    Haworth, S, Mitchell, R, Corbin, L, Wade, K, Dudding, T, Budu-Aggrey, A, Carslake, D, Hemani, G, Paternoster, L, Smith, GD, Davies, N, Lawson, D & Timpson, N, 2019. Nature Communications, vol 10. PMID: 30659178

  49. Assessment of reproducibility and biological variability of fasting and postprandial plasma metabolite concentrations using 1H NMR spectroscopy.
    Li-Gao, R., Hughes, D. A., le Cessie, S., de Mutsert, R., den Heijer, M., Rosendaal, F. R., Willems van Dijk, K., Timpson, N. J. & Mook-Kanamori, D. O., 20 Jun 2019. PLoS ONE. 14, 6, e0218549. PMID: 31220183

  50. Is Population Structure in the genetic biobank era irrelevant, a challenge, or an opportunity?
    Lawson, D., Davies, N., Haworth, S., Ashraf, B., Howe, L., Crawford, A., Hemani, G., Davey Smith, G. & Timpson, N., 27 Apr 2019. PMID: 31030318

  1. An estimate of the causal influence of body mass index on gut microbiome variation.
    David A Hughes, Charlie Hatcher, Kaitlin H Wade, Jeroen Raes, Nicholas J Timpson. Presented by D.A.H. as a poster and micro-talk at: ASHG 2022 Conference. Download poster here

  2. Long-term metabolomic effects of bariatric surgery.
    Madeleine L. Smith, Lucy J. Goudswaard, Laura J. Corbin, Nicholas J. Timpson, The By-Band-Sleeve Trial Management Group. Presented by M.S. as a poster at: Metabolomics 2022 Conference.

  3. Metaboprep: an R package for pre-analysis data description and processing of metabolomics data
    D.A. Hughes, K. Taylor,N. McBride, M.A. Lee, D. Mason, D.A. Lawlor, N.J. Timpson, L.J. Corbin. Presented by L.C. as a poster at: Metabolomics 2022 Conference. Download poster here

  4. Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis.
    Emma Hazelwood, Richard Martin, James Yarmolinsky. Presented as a talk and poster at: National Cancer Research Institute Cancer Conference. In addition, Emma was awarded the "NCRI Award" for a high quality abstract. Read the abstract here.

  5. The relationships between body mass index and metabolite response to a standardized meal challenge.
    David A. Hughes, Ruifang Li-Gao, Caroline J. Bull, Laura J. Corbin, Renée de Mutsert, Frits R. Rosendaal, Dennis O. Mook-Kanamori, Ko Willems van Dijk, Nicholas J. Timpson. Presented at: Metabolomics 2021 & IGES 2021. Download poster here.

  6. Metabolic features of colorectal cancer liability: life course study integrating genetic risk with repeated metabolomics.
    CJ Bull, JA Bell, N Murphy, JR Huyghe, NJ Timpson, MJ Gunter, EE Vincent. Presented at: The MR Conference 2021. Download poster here.

  7. Investigating a causal role for neutrophil count on P. falciparum severe malaria: a Mendelian Randomization study.
    Andrei Constantinescu, David Hughes, Ruth Mitchell, Borko Amulic, Jie Zheng, Caroline Bull, Siddhartha Kar, Nicholas Timpson, Emma Vincent. Presented at: The MR Conference 2021. Download poster here.

Contributions to COVID-19 Research

  1. Mental health before and during COVID-19 in two longitudinal UK population cohorts.
    Kwong, A. S. F., Pearson, R. M., Adams, M. J., Northstone, K., Tilling, K., Smith, D., Fawns-Ritchie, C., Bould, H., Warne, N., Zammit, S., Gunnell, D., Moran, P., Micali, N., Reichenberg, A., Hickman, M., Rai, D., Haworth, S., Campbell, A., Altschul, D., Flaig, R. & 4 others, , 24 Nov 2020, In: British Journal of Psychiatry. 10 p. PMID: 33228822

  2. The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture May-July 2020.
    Northstone, K., Smith, D., Bowring, C. E., Wells, N. S., Crawford, M., Haworth, S. J. & Timpson, N. J., 22 Sep 2020, In: Wellcome Open Research. 5, 210, 16 p. PMID: 32995559

  3. The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture April-May 2020.
    Northstone, K., Haworth, S., Smith, D., Bowring, C., Wells, N. & Timpson, N. J., 10 Jun 2020, In: Wellcome Open Research. 10 p. PMID: 33628949